Introduction:
An electric insecticide vaporizer is a device that heats the air in a room using a mains-operated heating element. When switched on, it vaporizes an insecticidal agent containing the active substance into the air of the treated room. The device is used by the population during the warm period of the year to kill mosquitoes, which are carriers of various fevers and create psychological discomfort at night. The active substances in insecticidal electric insecticide vaporizer agents utilize highly volatile pyrethroids, which have been linked to adverse effects on the nervous system, liver, and urinary system. Additionally, the issue of air pollution in living rooms, particularly for children, has become a pressing concern. The objective of this study was to examine the impact of chronic exposure to an insecticidal agent based on transfluthrin in the form of a liquid, combined with an electric insecticide vaporizer, on the functional state of white rats from birth to puberty.

Methods:
The experiments were conducted on 80 mongrel white rats housed in the vivarium of the Institute on a standard food ration. The experimental groups consisted of 12 animals (males and females). From the moment of birth, the animals were placed in chambers (0.5 m³) with an electric insecticide vaporizer that was activated for 6, 60, 300, and 1440 min/day for a period of five months. Toxicological methods of nervous system evaluation, biochemical methods of blood serum and urine examination, and general blood analysis were employed.

Results:
The long-term inhalation effect of an insecticidal electrofumigating agent based on transfluthrin on the functional state of white rats was studied. The agent's impact on the number of eosinophils in the blood, which may indicate the development of allergic reactions in the rat organism, was evaluated. Additionally, the agent's effect on the nervous system function was examined, which confirmed the available literature data. Finally, the agent's impact on metabolic processes in the rat liver, manifested by changes in some indicators (carbohydrate and protein metabolism, creatinine synthesis), was established.

Conclusions:
The results of the conducted studies have led to the establishment of physiological and biochemical biomarkers of the effect of the electrofumigating agent based on transfluthrin. It has been demonstrated that the prolonged and constant use of electric insecticide vaporizer agents can have harmful effects on the organism. It is safer to use these products in ventilated rooms in accordance with the application rate.

Conflicts of interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and was first published here.

Funding:
This research received no external funding from any funding agency in the public, commercial, or not-for-profit sectors.