CONFERENCE PROCEEDING
The fosthiazate toxic effect with repeated oral intake into the body of warm -blooded animals
1
FBES «F.F. Erisman Federal scientific center of hygiene» of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Institute of Hygiene, Toxicology of Pesticides and Chemical Safety, Mytishchi, Russia
2
Toxicology Medical School, University of Crete, Heraklion, Greece
Publication date: 2024-04-16
Public Health Toxicol 2024;4(Supplement Supplement 1):A7
KEYWORDS
ABSTRACT
Introduction:
Toxicological and hygienic assessment fosthiazates’ technical product danger with repeated oral intake into the body of warm-blooded animals was carried out during chronic toxicity study.
Methods:
In a 12-month experiment 0,42; 2,08; 8,94 mg/kg body weight doses were tested on male rats. The object of the study is outbred white male rats (n=80), their body weight before the experiment was 180-190 g. Animals divided into 4 groups, each group consisted of 20 animals. The appearance, general condition, behavioral responses, the clinical signs of intoxication were monitored, time of death was recorded, body weight was determined, changes in physiological, biochemical and haematological parameters were recorded. The nervous system state was assessed by the animal’s ability to summarize subthreshold impulses (summation-threshold indicator - STI) and by behavioral responses.
Results:
Behavioral responses assessment (total activity, path length, rest time, hole-board test, approximate reaction) showed a statistically significant change in the maximum dose, a decrease in the hole-board test was revealed at the 12th month of the study. There were no statistically significant differences in the assessment of STI. When assessing the biochemical blood parameters, a statistically significant increase in the level of Alanine aminotransferase (ALT), triglycerides and a chloride, total protein, Cholinesterase decrease at a dose of 8.94 mg/kg were revealed compared with the control group. Evaluation of hematological parameters revealed a statistically significant decrease in hemoglobin at the maximum dose in comparison with the control group. Statistically significant changes in the activity of antioxidant defense system enzymes, a decrease in the activity of glutathione reductase was revealed throughout the experiment relative to the control group values.
Conclusions:
As a result of the chronic toxicity study, NOEL was established at the level of 0,4 mg/kg according to the changes in biochemical and haematological parameters.
Conflicts of Interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and published here firstly.
Toxicological and hygienic assessment fosthiazates’ technical product danger with repeated oral intake into the body of warm-blooded animals was carried out during chronic toxicity study.
Methods:
In a 12-month experiment 0,42; 2,08; 8,94 mg/kg body weight doses were tested on male rats. The object of the study is outbred white male rats (n=80), their body weight before the experiment was 180-190 g. Animals divided into 4 groups, each group consisted of 20 animals. The appearance, general condition, behavioral responses, the clinical signs of intoxication were monitored, time of death was recorded, body weight was determined, changes in physiological, biochemical and haematological parameters were recorded. The nervous system state was assessed by the animal’s ability to summarize subthreshold impulses (summation-threshold indicator - STI) and by behavioral responses.
Results:
Behavioral responses assessment (total activity, path length, rest time, hole-board test, approximate reaction) showed a statistically significant change in the maximum dose, a decrease in the hole-board test was revealed at the 12th month of the study. There were no statistically significant differences in the assessment of STI. When assessing the biochemical blood parameters, a statistically significant increase in the level of Alanine aminotransferase (ALT), triglycerides and a chloride, total protein, Cholinesterase decrease at a dose of 8.94 mg/kg were revealed compared with the control group. Evaluation of hematological parameters revealed a statistically significant decrease in hemoglobin at the maximum dose in comparison with the control group. Statistically significant changes in the activity of antioxidant defense system enzymes, a decrease in the activity of glutathione reductase was revealed throughout the experiment relative to the control group values.
Conclusions:
As a result of the chronic toxicity study, NOEL was established at the level of 0,4 mg/kg according to the changes in biochemical and haematological parameters.
Conflicts of Interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and published here firstly.
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