For several decades, glyphosate has been one of the most widely used herbicides in the world, but the safety of glyphosate and its commercial formulations is still controversial. A study of 12-month oral exposure to glyphosate acid in male albino rats at doses of: 0.15, 20, 200, 2000, 20000 ppm when consumed with specially prepared soy (heat-treated to deactivate the trypsin inhibitor) in structural and functional parameters revealed, compared with control, non-acting doses for various studied organs: - glyphosate acid exposure at the maximum dose (20,000 ppm) doesn’t affect on small and large intestines, liver, kidney, spleen, testis, heart, thymus, adrenal and thyroid glands; - exposure to glyphosate acid at a dose of 100 mg/kg b.w. (2000 ppm) does not affect the lungs; - exposure to glyphosate acid at a dose of 100 mg/kg b.w. (2000 ppm) does not affect the pancreas. Pathomorphological studies of animals of all groups were conducted. A complete necropsy of the bodies of rats of the above groups was performed. Morphological, morphometric and stereometric analyzes were used. Pathomorphological study of indicators in 13 organs (thyroid gland, thymus, heart, lungs, stomach, liver, spleen, pancreas, small and large intestines, kidneys, adrenal glands, testes) in the animals’ lungs with a maximum glyphosate acid exposure at a dose of 20,000 ppm showed a tendency to more than double the proportion of emphysematous tissue. In the pancreas, at the maximum exposure to glyphosate acid at a dose of 20,000 ppm, a tendency to develop lipomatosis was noted. In the rest of the organs in the 12-month experiment, no statistically significant changes were found among the studied parameters in all groups. Based on the results of a chronic experiment, the value of the inactive dose (NOEL) of glyphosate acid was set at 2000 ppm, which does not contradict the previously established toxicity parameters of the compound.

Conflicts of Interest:
The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and published here firstly.