CONFERENCE PROCEEDING
Personalized nutrition for the prevention of cardiovascular diseases
 
More details
Hide details
1
University College London, London, United Kingdom
 
 
Publication date: 2022-05-27
 
 
Public Health Toxicol 2022;2(Supplement 1):A54
 
KEYWORDS
ABSTRACT
Emerging technologies in nutrigenomics and deep phenotyping have allowed us to collect a vast range of data on genetic indicators, clinical biomarkers, sensitive body composition metrics and dietary intake data. It is clear that the interplay between genetics, dietary habits and lifestyle determines a person’s risk to develop cardiovascular disease. While this relationship is less plastic in the case of monogenic or familial hypercholesterolemia (FH), the most common hypercholesterolemia cases are of polygenic nature and the interactions between genetic variation and environmentally induced responses are more plastic. Despite the nature of the pathology, the key challenge in hypercholesterolemia remains in the mismatch between genes involved in lipid metabolism and modern diet and a variety of lifestyle factors. The field of precision nutrition is focused on unravelling the factors that explain the interindividual variability in response to lifestyle and nutritional interventions. Latest advances in this area have explored how new applications of metabolomics, nutrigenomics and microbiota profiling could provide new avenues to successfully implement innovative precision nutrition approaches to identify health risks and implement preventative strategies to avoid disease. The current challenge remains to meaningfully translate these findings into clinically relevant pieces of information.
 
REFERENCES (5)
1.
Asnicar F, Berry SE, Valdes AM, et al. Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals. Nat Med. 2021;27(2):321-332. doi:10.1038/s41591-020-01183-8
 
2.
de Toro-Martín J, Arsenault BJ, Després JP, Vohl MC. Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome. Nutrients. 2017;9(8):913. doi:10.3390/nu9080913
 
3.
Kalea AZ, Drosatos K, Buxton JL. Nutriepigenetics and cardiovascular disease. Curr Opin Clin Nutr Metab Care. 2018;21(4):252-259. doi:10.1097/MCO.0000000000000477
 
4.
Ramos-Lopez O, Milagro FI, Riezu-Boj JI, Martinez JA. Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition. Inflamm Res. 2021;70(1):29-49. doi:10.1007/s00011-020-01425-y
 
5.
Tuncay C, Ergoren MC. A systematic review of precision nutrition and Mediterranean Diet: A personalized nutrition approaches for prevention and management of obesity related disorders. Clin Nutr ESPEN. 2020;38:61-64. doi:10.1016/j.clnesp.2020.04.005
 
ISSN:2732-8929
Journals System - logo
Scroll to top