In flow controlled synthesis of blood clots
More details
Hide details
Departament de Ciència dels Materials i Química Física, Institut de Química Teòrica y Computacional (IQTC), Barcelona, Spain
FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
Discovery Foundation, Arkalochori, Greece.
EXPERIAN, Lisbon, Portugal
Simulation Technologies Laboratory (SIMTECH Lab), Transport Phenomena Research Centre, Engineering Faculty, Porto University, Porto, Portugal
Institute of Robotics and Intelligent Systems, ETH Zurich, Zürich, Switzerland
Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain
Publication date: 2021-09-27
Public Health Toxicol 2021;1(Supplement Supplement 1):A53
Nanoscience is one of the most developed fields in today's world. Its applications cover examples in natural, physical, pharmacological, and chemical sciences, with a high impact on human advancement in the present and the future. The application of nanotechnologies includes several advantages, for example, the decrease of manufacturing costs, the development of new technologies based on new properties, and the mitigation of side effects on human and environmental health.
A stroke is a medical condition where poor blood flow causes the cell’s death because of a cerebrovascular or cardiovascular blockage. Strokes have been reported as one of the primary causes of death in 2019, with a 22% increase since the beginning of this century. This condition was responsible for 8.9 million deaths in 2019, with an expected increase, consequence of its relationship with the SARS-COV-2 (COVID19) virus1. Its high impact in human health has pushed scientists to develop and improve technologies for the study and treatment of strokes, as well as the relationship between stroke and viral diseases2-4. Current treatments for the disease have not overcome the medical limitations, where the administration times, drug efficiency, complex medical interventions, and secondary effects (such as haemorrhage) are liable for causing deaths among the treated people5. In this context, nanoscience concepts such as Lab-On-A-Chip technologies, controlled drug carrier transport, and micro-particle synthesis and manipulation can serve as a tool to overcome current challenges in stroke therapy. In this contribution, we will show how microfluidic technologies can have a great impact on this field enabling a controlled localization of clots as well as the study of their dissolution.
The authors acknowledge support from the European Union's Horizon 2020 research and innovation programme under grant agreement No 952152, project ANGIE (MAgnetically steerable wireless Nanodevices for the tarGeted delivery of therapeutIc agents in any vascular rEgion of the body).
The top 10 causes of death. World Health Organization. December 9, 2020. Accessed September 15, 2021.
Iba T, Warkentin TE, Thachil J, Levi M, Levy JH. Proposal of the Definition for COVID-19-Associated Coagulopathy. J Clin Med. 2021;10(2):191. doi:10.3390/jcm10020191
Buzhdygan TP, DeOre BJ, Baldwin-Leclair A, et al. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood-brain barrier. Neurobiol Dis. 2020;146:105131. doi:10.1016/j.nbd.2020.105131
Al-Ani F, Chehade S, Lazo-Langner A. Thrombosis risk associated with COVID-19 infection. A scoping review. Thromb Res. 2020;192:152-160. doi:10.1016/j.thromres.2020.05.039
Shimizu S. Routes of Administration. In: Hedrich H, ed. The Laboratory Mouse. 2nd ed. Elsevier; 2012:709-725. Accessed September 15, 2021.
Journals System - logo
Scroll to top