The improvement of physicochemical methods for the analysis of chemical ingredients, along with the establishment of new properties, makes it possible to identify the toxic effect of some ingredients widely used in cosmetic and pharmaceutical practice. So, last year, manufacturers of anti-dandruff rinse-off products faced the need to replace such a popular pyrithione zinc due to proven carcinogenicity when applied to the skin [1]. In this regard, the search for new highly effective and safe ingredients for the treatment and improvement of the aesthetic appearance of the skin and hair of the head in various dermatological diseases is relevant. Attention should be paid to humic substances, which have a wide range of biological activity and no side effects. Since the main form of rinse-off anti-dandruff compositions is liquid shampoo, the water solubility of the ingredients included in such compositions is significant. Therefore, in this research, the main- attention was paid to an aqueous solution of humic substances, which were isolated by alkaline extraction with a 0.1 M NaOH solution from a commercial sample of lowland peat. In the work an antifungal effect was established against fungal microorganisms: Saccharomyces cerevisiae, Candida albicans, Aspergillus niger. The fungal nature of diseases of the scalp is directly related to an increase in the growth of opportunistic fungi of the genus Malassezia, therefore, additional studies are required to evaluate the fungicidal action of humic substances against these fungi. However, preliminary results and literature data [2] allow us to recommend humic substances for introduction into rinse-off cosmetic products against dandruff and in adjunctive therapy for seborrheic dermatitis and psoriasis.

Conflicts of Interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and published here firstly.