One of the promising tasks of polymer materials science is the development of wound coatings and biodegradable matrices that ensure the regeneration of living tissues. A promising biodegradable natural polymer used to solve this problem is silk fibroin from the cocoons of the silkworm Bombyx mori [1]. The development of fibroin modification methods will make it possible to obtain water-insoluble biodegradable fibrous and hydrogel materials. Due to the fact that fibroin-based systems dissolve in water, it is possible to use a method of electroforming such materials. The methods of converting chitosan and fibroin compositions into a water-insoluble state were substantiated: conformational transition in fibroin and chemical crosslinking, on this basis technological solutions in the field of fiber molding based on biopolymers were proposed. New features of the mechanisms of interaction of fibroin and chitosan polymers with genipin have been established, which made it possible to separate the stages of modifying the fiber-forming polymer in the molding solution and forming a cross-linked spatial network leading to the production of water-insoluble fiber. It was found, that the introduction of fibroin leads to the suppression of the inflammatory response of tissues, increased cell adhesion and proliferation of living cells on materials from a chemical cross-linked composition of fibroin and chitosan [2]. The prolonging effect of immobilization of biologically active compounds in the structure of fibroin-containing cross-linked chitosan films has been established.

Conflicts of Interest:
The authors declare that they have no conflict of interest in the publication of this article. The authors have no conflicts of interest to report in this work. Abstract was not submitted elsewhere and published here firstly.

Funding:
This work was supported by Russian Science Foundation (project no. 22-13-00261).