Long-term metabolic and inflammatory effects of second-generation antipsychotics: A study in mentally disordered offenders
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Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Thessaloniki, Greece
1st Department of Psychiatry, Sector of Neurosciences and Sensory Organs, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
Department of Forensic Psychiatry, Psychiatric Hospital of Thessaloniki, Thessaloniki, Greece
Psychiatric Clinic, General University Hospital of Larissa, Larissa, Greece
Department of Practical Abilities-Human Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania
Emilia Vassilopoulou   

Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, GR-57400, Sindos, Thessaloniki, Greece
Publication date: 2022-05-27
Public Health Toxicol 2022;2(Supplement 1):A99
This paper combines forensic psychiatry, antipsychotics drug and metabolic disturbances. It refers to mentally disordered offenders provided with forensic psychiatric care are often treated with second generation antipsychotic medication and experience metabolic and inflammatory side effects. Three-year variability of selected anthropometric, biochemical and inflammatory markers was monitored in forensic psychiatric patients receiving antipsychotic (AP) medication for more than five years, according to the type of ΑP. Thirty-five patients with psychotic disorders were classified into two groups based on the type of AP. Specifically: AP1, related to a lower risk, and AP2, related to an increased risk of weight gain and metabolic complications. Biochemical, hematological, anthropometric, blood pressure, and medication data were retrieved from the individual medical files. No significant differences in weight and glucose and cholesterol levels were observed, but patients taking AP2 more often needed drugs to control diabetes mellitus, lipidemia, and cardiovascular disease. In those taking AP1, the mean HDL level decreased significantly over time (p < 0.05) and a higher proportion developed higher blood pressure (52.9% of AP1 vs. 16.7% AP2). In the AP2 group the median level of C-reactive protein (p < 0.001) and the white blood cell count increased over the three years (p < 0.001).
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