Biomimetics of proteins: Artificial polymers made of α-amino acids
More details
Hide details
Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Tbilisi, Georgia
Publication date: 2021-09-27
Public Health Toxicol 2021;1(Supplement 1):A9
Proteins are one of the most appropriate biomaterials for a variety of biomedical applications including resorbable surgical and pharmaceutical devices owing to their innate affinity to tissues, enzymatic biodegradability with releasing “the bricks of life” - α-amino acids (α-AAs) which could be assimilated by the organism promoting in that way tissue regeneration. However, the proteins have some serious shortcomings among which the most important is immunogenicity that is attributed to their molecular architecture.
More promising are α-AA based synthetic biodegradable (AABB) polymers having a new macromolecular architecture less recognizable by the immune system of the living organism. The presentation deals with an overview of the main families of the α-AA based synthetic polymers such as poly(amino acid)s, pseudo-poly(amino acid)s, polydepsipeptides, and provides somewhat more expanded information about the fourth class - so-called pseudo-proteins1-4 which represent relatively new and broad family of the biodegradable polymers qualified for numerous biomedical applications5-9, including nano-vehicles for targeted drug delivery10. A new class of pseudo-proteins composed of non-proteinogenic amino acids were obtained as well11. These new polymers are expected to have as wide range of biological activities.
This work was supported in part by the International Science and Technology Center [Grant # A-2289], and Shota Rustaveli NSF of Georgia [Grant # FR17-102].
Kobauri S, Kantaria T, Kupatadze N, Kutsiava N, Tugushi D, Katsarava R. Pseudo-proteins: A new family of biodegradable polymers for sophisticated biomedical applications. Nano Techn & Nano Sci J. 2019;1(1):37-42. Accessed August 1, 2021.
Zavradashvili N, Puiggali J, Katsarava R. Artificial Polymers made of α-amino Acids - Poly(Amino Acid)s, Pseudo-Poly(Amino Acid)s, Poly(Depsipeptide)s, and Pseudo-Proteins. Curr Pharm Des. 2020;26(5):566-593. doi:10.2174/1381612826666200203122110
Katsarava R, Kantaria T, Kobauri S. Pseudo-proteins and related synthetic amino acid based polymers (Review). J Mater Educ. 2021;43(1-2):33.
Yousefzade O, Katsarava R, Puiggalí J. Biomimetic Hybrid Systems for Tissue Engineering. Biomimetics (Basel). 2020;5(4):49. doi:10.3390/biomimetics5040049
Lendlein A, Sisson A, eds. Handbook of Biodegradable Polymers: Synthesis, Characterization and Applications. Wiley; 2011. Accessed September 8, 2021.
Katsarava R, Gomurashvili Z. Biodegradable Polymers Composed of Naturally Occurring α-Amino Acids. In: Lendlein A, Sisson A, eds. Handbook of Biodegradable Polymers: Synthesis, Characterization and Applications. Wiley; 2011:107-131. Accessed September 8, 2021.
Memanishvili T, Zavradashvili N, Kupatadze N, et al. Arginine-Based Biodegradable Ether–Ester Polymers with Low Cytotoxicity as Potential Gene Carriers. Biomacromolecules. 2014;15(8)2839-2848. doi:10.1021/bm5005977
Katsarava R, Kulikova N, Puiggalí J. Biodegradable Polymers Composed of Amino Acid Based Diamine-Diesters - Promising Materials for the Applications in Regenerative Medicine. Jacobs Journal of Regenerative Medicine. 2016;1(3):012. Accessed September 8, 2021.
Kantaria T, Kantaria T, Kobauri S, et al. Biodegradable Nanoparticles Made of Amino-Acid-Based Ester Polymers: Preparation, Characterization, and In Vitro Biocompatibility Study. Applied Sciences. 2016;6(12):444. doi:10.3390/app6120444
Zavradashvili N, Jokhadze G, Gverdtsiteli M, Tugushi D, Katsarava R. Biodegradable Functional Polymers Composed of Naturally occurring Amino Acids. Research & Reviews in Polymer. 2017;8(1):105. Accessed September 8, 2021.
Zhang W, Kantaria T, Zhang Y, et al. Biodegradable Nanoparticles Based on Pseudo-Proteins Show Promise as Carriers for Ophthalmic Drug Delivery. J Ocul Pharmacol Ther. 2020;36(6):421-432. doi:10.1089/jop.2019.0148
Kantaria T, Kupatadze N, Otinashvili G, et al. New biodegradable poly(ester amide)s composed of non-proteinogenic α-amino acids. 1st International Conference "Current State of Pharmacy and Prospects of its Development" dedicated to 100th anniversary of Yerevan State, Yerevan, 2018.